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M9480008.TXT
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1994-08-09
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Document 0008
DOCN M9480008
TI CD8+ polylobated T-cell leukemia/lymphoma. A case report with
immunophenotypic, ultrastructural, gene rearrangement, karyotypic, and
DNA content analysis and autopsy description.
DT 9410
AU Friedman HD; Hutchison RE; Smith JR; Gonchoroff NJ; Stein CK; Poiesz BJ;
Department of Pathology and Laboratory Medicine, Syracuse, NY; 13210.
SO Arch Pathol Lab Med. 1994 Jul;118(7):722-7. Unique Identifier : AIDSLINE
MED/94296223
AB Polylobated lymphoma is a morphologic variant of malignant lymphoma
characterized by large pleomorphic neoplastic cells with polylobated
nuclei. We report an unusual case in a 57-year-old man with a 9-year
history of an antecedent low-grade peripheral T-cell lymphoma with
dermal involvement. The polylobated lymphoma expressed the CD2, 8, 45,
and DR surface antigens and had a clonally rearranged T-cell receptor
beta-chain gene. The DNA content analysis indicated that most of the
neoplasm was DNA diploid and tetraploid, with a high S phase.
Cytogenetic analysis demonstrated the presence of a clone with an
abnormal karyotype 45, X, -Y, -1, -10, -10, -17, -19, +5 mar. Serology
and polymerase chain reaction analysis showed no evidence of retroviral
infection (human immunodeficiency virus types 1 and 2 and human T-cell
lymphotropic virus types I and II). We review the literature on
polylobated T-cell lymphoma.
DE Antigens, CD8/*ANALYSIS Case Report DNA, Neoplasm/ANALYSIS Gene
Rearrangement Human Immunohistochemistry Immunophenotyping
Karyotyping Lymphoma, T-Cell/GENETICS/IMMUNOLOGY/*PATHOLOGY Male
Microscopy, Electron Middle Age JOURNAL ARTICLE REVIEW REVIEW OF
REPORTED CASES
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).